Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions.
Guerendo made a successful return from a one-game layoff due to foot and hamstring injuries Week 17. The fourth-round rookie looked no worse for wear, generating 99 yards from scrimmage in a pass-heavy game plan. The only negative aspect of Guerendo's fantasy line was a lack of trips to the end zone after quarterbacks Brock Purdy (elbow) and Joshua Dobbs vultured a pair of short touchdown rushes. Guerendo may find himself more involved as a rusher if San Francisco's injured starting QB is unable to suit up against the Cardinals on Sunday.