Guerendo will not practice Wednesday due to foot and hamstring injuries, David Lombardi of SFStandard.com reports.
Guerendo played through a foot sprain in last Thursday's 12-6 loss to the Rams, and though he didn't experience any reported in-game setbacks with that injury, he's emerged from the contest with a new health concern. With Christian McCaffrey (knee) and Jordan Mason (ankle) both on injured reserve, the 49ers could realistically be taking a cautious approach to Guerendo's health, but his activity will now need to be monitored during practices Thursday and Friday. Patrick Taylor, Israel Abanikanda and practice-squad member Ke'Shawn Vaughn, are San Francisco's available backfield options behind Guerendo heading into a road matchup against the Dolphins on Sunday.