Garoppolo (thumb) isn't practicing Friday, Matt Barrows of The Athletic reports.
Another absence for Garoppolo has Trey Lance trending toward his second NFL start, with the first being a 17-10 loss at Arizona back in Week 5. The rookie will get an easier draw if he gets the nod this Sunday, as the 49ers are hosting the 4-11 Texans and now have TE George Kittle in the lineup.