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Garoppolo (calf) isn't on the field for Thursday's practice, David Lombardi of The Athletic reports.

Though head coach Kyle Shanahan has thus far been unwilling to rule Garoppolo out for Sunday's game against the Cardinals, the quarterback said himself after exiting the Week 4 loss to the Seahawks that he expects to miss a couple of weeks, per Cam Inman of The San Jose Mercury News. Based on Garoppolo's consecutive absences at practice to begin Week 5 prep, any hope of him playing in Arizona seems to be dwindling. Trey Lance will direct the first-team offense for the second day in a row Thursday and is trending toward his first career start this weekend.

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