Goodwin (knee) was placed on injured reserve Tuesday, Field Yates of ESPN reports.
The wideout had a regular role in the offense during the 49ers' first five games of the season, but Goodwin had minimal results, namely 11 receptions (on 15 targets) for 181 yards and one touchdown. He then missed some time due to a personal matter and was buried on the depth chart thereafter due to the addition of Emmanuel Sanders and the emergence of Deebo Samuel and Kendrick Bourne. Goodwin will focus on rehabbing his knee injury moving forward while his teammates seek the No. 1 seed in the NFC side of the playoffs.