Williams (knee) was moved to the reserve/PUP list by the 49ers on Sunday.
Williams is still recovering from a torn ACL that he suffered in November 2025, and he was unable to practice or play during the preseason. The 22-year-old will now be forced to miss at least four contests to open the regular season, and the earliest he'll be able to return to action is Week 5 against the Seahawks on Oct. 11.