Bosa made four tackles (three solo) in the 49ers' 27-7 Week 1 victory over the Rams.
Bosa showed out as a run defender during his first game back from an ACL injury that he suffered in Week 3 of the 2025 season. The defensive end didn't notch a sack in the Week 1 contest, but he was a strong presence on the edge against the Rams' run and pass game. The 28-year-old played 59 percent of the defensive snaps, in line with the other starters on the team's defensive line.