James only logged seven offensive snaps (plus 11 on special teams) and was not targeted in Monday's 34-24 loss to Buffalo.
Brandon Aiyuk (reserve\COVID-19) returned from a one-week absence and pushed James from No. 2 down to No. 4 on the wide receiver depth chart with Kendrick Bourne sticking in the slot. Injuries allowed James to start the 49ers' three previous contest, and the 25-year-old turned one of those into a monster performance (nine catches for 184 yards and a touchdown against Green Bay in Week 9). With San Francisco's receiving corps back at full strength, James can safely be left on waivers heading into a Week 14 matchup with the Washington Football Team.