James (ankle) is listed as questionable for Thursday's game against the Packers, Nick Wagoner of ESPN.com reports.
If he can move past the ankle injury to play Thursday, James would likely be in store for the biggest offensive role of his career. The 49ers placed fellow wideout Kendrick Bourne (illness) on the reserve/COVID-19 list earlier Wednesday, and Dante Pettis no longer on the team. Additionally, top receiver Deebo Samuel (hamstring) has also been ruled out. If James can't go, on the other hand, the 49ers will be down to only Brandon Aiyuk and Trent Taylor as their healthy options at wide receiver.