San Francisco head coach Kyle Shanahan said Monday that Dwelley sustained a right high-ankle sprain in Sunday's 42-19 win over the Eagles and is expected to miss time, Nick Wagoner of ESPN.com reports.
Dwelley has just one reception for 12 yards on two targets this season, but he's been active for all 12 of San Francisco's games and fills a key role as a blocker and on special teams. Assuming the ankle sprain results in Dwelley missing this Sunday's game against the Seahawks, seventh-round rookie Brayden Willis could suit up as the 49ers' No. 3 tight end behind George Kittle and Charlie Woerner.