Williams (knee) is listed as questionable for Sunday's game against New Orleans, Matt Maiocco of NBC Sports Bay Area reports.
Williams didn't practice at all Wednesday or Thursday before logging a limited session Friday. If Williams isn't able to suit up this weekend, it would be a huge blow to a 49ers offense that will already be without starting quarterback Brock Purdy (toe) and tight end George Kittle (hamstring). Spencer Burford would likely step into a starting role at left tackle if Williams can't go.