Knox's role could take on greater importance Sunday with wide receivers Cole Beasley and Gabriel Davis both ruled out while in the COVID-19 protocols.
Knox is normally a big part of the offense anyway, but with two of the team's top five receiving options out, expect him to see a high target volume in the most important game of the season for the Bills. While the increased opportunity will be nice for managers needing a big game out of the third-year tight end, it's worth noting the Patriots have the league's third-best past defense, plus there's a chance of wind and snow for the game.