Knox suffered a broken bone in his hand during Monday's 34-31 loss to the Titans, Mike Garafolo of NFL Network reports.
Knox was able to handle some plays after suffering the injury, including throwing a two-point conversion to Josh Allen, but it looks like it's possible he could need to miss time. The Bills will enjoy a bye Week 7 before taking on Miami on Oct. 31, so Knox will at least benefit from extra time to rest up.