Carter (wrist) is questionable to play against the 49ers on Sunday, Alec White of the Bills' official site reports.
Carter was placed on injured reserve Oct. 25 due to a wrist injury. He has been sidelined for the Bills' last four regular-season games, and he has a good chance at being activated before the 4:00 p.m. ET deadline Saturday after logging full practices all week. If he does return, Carter will serve in a rotational role at defensive tackle Sunday behind DaQuan Jones and Ed Oliver.