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Bills head coach Sean McDermott said Tuesday that he's optimistic Cook (toe) will be available to play Sunday against the Titans, Matt Parrino of The Syracuse Post-Standard reports.

Though Cook was listed as questionable heading into Monday's game against the Jets, reports leading up to the contest suggested he was on track to play. However, Cook didn't make enough progress in his recovery from a toe injury and ended up on the inactive list for the first time all season, with the Bills turning to rookie Ray Davis and veteran Ty Johnson to fill the backfield in a 23-20 win. Davis (20 carries for 97 yards, three receptions for 55 yards) was impressive in his first extended NFL action to date, and his big performance could prompt the Bills to take a cautious approach with Cook during practice this week. McDermott indicated that a decision on Cook's status may not be made until closer to game day, per Jay Skurski of The Buffalo News.

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