Sampson (knee) is expected to miss "significant time," Jeremy Fowler of ESPN.com reports.
Sampson hurt his left knee in Sunday's Week 1 loss to Jacksonville and was on crutches while wearing a brace after the game. It appears that further evaluation on the running back has concluded that Sampson is dealing with a severe injury. It's not yet clear exactly how much time he'll miss, though there's certainly a chance he'll end up on IR. Raheim Sanders likely will take on a bigger role in Sampson's absence, and Jaleel McLaughlin could be summoned from the practice squad.