Williams (knee) was designated to return from injured reserve Wednesday, Ian Rapoport of NFL Network reports.
Williams suffered the injury Week 1 and has been sidelined since. He'll now have a 21-day window to practice with the team before needing to be placed back on the 53-man roster. However, if he's healthy enough, he could return as soon as Sunday against the Bears. The Alabama product was signed to a two-year, $30 million contract in free agency to anchor the right side of the Cardinals' offensive line, so his potential return should be a significant boost for Arizona.