The Cardinals placed Williams (knee) on injured reserve Wednesday.
Williams was brought in to anchor the right side of Arizona's offensive line, but he'll have to miss at least the next four games due to a knee issue suffered Week 1. Kelvin Beachum will step up as the starting right tackle in Williams' stead. Per Josh Weinfuss of ESPN.com, coach Jonathan Gannon said the Cardinals are still gathering information on whether Williams will require surgery.