Guyton was a limited participant at Wednesday's practice due to a hamstring injury.
With Keenan Allen (hamstring) seemingly trending toward a second straight absence Sunday against the Chiefs, Guyton's Week 17 status gains added import. If Allen ends up out and Guyton is cleared to play this weekend, he would be taking aim at a Kansas City squad that's likely to be sitting or limiting some of its key defensive players, given that the Chiefs have already clinched the AFC's No. 1 seed.