Guyton caught his lone target for four yards in Sunday's 34-28 win against the Jets.
Coming off last week's season high in receptions, Guyton did not receive the same amount of opportunities in this matchup against the Jets. His limited opportunities were due to Keenan Allen's incredible performance, as Allen tied the franchise record for most receptions in a single game. Sunday's matchup against the Bills might make it difficult to give the 23-year-old Guyton more chances to be involved.