The Chargers placed Smith (undisclosed) on injured reserve Tuesday, Jeff Miller of the Los Angeles Times reports.
Smith dealt with a core muscle injury early in training camp and then spent time on the COVID-19 list, but his current health concern is unknown. The 28-year-old is eligible to return from IR after Week 3 of the regular season. The rookie Asante Samuel will likely step in as the primary backup behind Chris Harris and Michael Davis while Smith is sidelined.