Pacheco (shoulder) wasn't spotted at practice Friday, Adam Teicher of ESPN.com reports.
Pacheco didn't practice Wednesday or Thursday, so his apparent absence from Friday's session doesn't bode well for his chances of suiting up Sunday against the Bills. Kansas City will release its final Week 14 injury report later Friday, and if Pacheco is ruled out for the contest, Pete Sweeney of ArrowheadPride.com suggests that Clyde Edwards-Helaire would be in line to serve as the Chiefs' lead option on the ground, with Jerick McKinnon (groin) operating as the team's passing-down back.