Willis recorded 63 tackles (43 solo), 1.5 sacks, five pass breakups, two interceptions and one fumble recovery across 11 games in 2021.

Willis missed a total of six games this season due to groin and calf injuries, plus a stint in the league's COVID-19 protocols. When healthy, Willis did handle a starting role, providing modest value in IDP formats due to his tackle numbers. The 25-year-old is set to play out the final year of his rookie contract with Indianapolis during the 2022 season.