Hewitt (ankle) was ruled out for Sunday's game against Jacksonville, Mike Wells of ESPN.com reports.
Hewitt sustained the ankle injury during Week 8 against the Raiders or at some point during the Colts' bye, as he was unable to practice this week. The 27-year-old has been targeted once this season, as he is typically utilized as a blocker. Mo Alie-Cox will serve as the Colts' No. 3 tight end with Erik Swoope (knee) also ruled out.