Gardner (calf) has been ruled out ahead of Monday night's matchup against the 49ers, Amanda Foster of the Colts' official site reports.
The Cincinnati product is now in line to miss his third consecutive game due to a calf injury sustained in the Week 13 loss to the Texans. While Gardner remains sidelined for Monday night's contest, expect Jaylon Jones and Mekhi Blackmon to operate as Indianapolis' top boundary cornerbacks.