Wilson (ankle) has been ruled out for Thursday's game in New Orleans, Ed Werder of ESPN reports.
Wilson had season highs for targets (10) and yards (104) in the Cowboys' Thanksgiving Day loss to Las Vegas, handling a larger-than-usual role with both CeeDee Lamb (concussion) and Amari Cooper (COVID-19) unavailable. Wilson injured his ankle along the way however, while Lamb is now off the injury report and Cooper is listed as questionable but expected to play. Noah Brown is the likely No. 4 receiver with Wilson out, or potentially the No. 3 option in the event Cooper doesn't end up playing.