Locke (concussion) won't play in Sunday's game against the 49ers, Patrik Walker of the team's official site reports.
Locke suffered a concussion in Week 8 versus the Cardinals. While he was cleared to play in Week 9 against the Colts, he suffered another concussion. Now, Locke will miss at least one game, though the team will presumably be overly cautious before allowing him to get back on the field, meaning Markquese Bell may be in line for more snaps.