Thompson entered Thursday night's 31-10 loss to the Bills for an injured Tua Tagovailoa (concussion) with 4:10 remaining in the third quarter and completed eight of 14 passes for 80 yards with no touchdowns or interceptions. He also rushed once for four yards.
Thompson fired incomplete and took a sack on his first two dropbacks, but he was able to start getting into somewhat of a rhythm on his next possession. Nevertheless, the game was essentially out of reach by early in the final period, and Thompson subsequently led an offense that was without Tyreek Hill or Jaylen Waddle due to the two being pulled early from the lopsided loss. Thompson had some moments of success as a starter in Tagovailoa's stead back in 2022, and he'll be called on to fill in again in a Week 3 road matchup against the Seahawks on Sunday, Sept. 22 if Tagovailoa is unable to clear concussion protocol.