James missed Wednesday's practice with an ankle injury, Dan Duggan of The Athletic reports.
The injury might explain, at least partially, why James dropped from 31 or more snaps and five or more targets in each of the Giants' first three games down to 21 snaps (32 percent) and three targets in Sunday's 20-12 win over the Bears. His role was scaled back early on, however, so it may have been more about the Giants giving Kenny Golladay (knee) another chance without taking David Sills off the field. Golladay then left the game early, at which point Darius Slayton picked up significant playing time for the first time this season. At this early point in the week with so may receivers injured, it's nearly impossible to decipher who will get targets for the Giants this Sunday against the Packers in London.