James didn't practice Wednesday due to a knee injury, Dan Salomone of the Giants' official site reports.
With touchdown catches in two straight games, James seemingly is on the upswing in the Giants' passing game, but his health is now a question mark as the team begins Week 13 prep. His absence from practice Wednesday is somewhat of a concern, but he at least has two more opportunities to mix into drills this week before he potentially is given a designation ahead of Sunday's contest against the Commanders.