Shepard picked up a toe injury during Sunday's contest at Chicago.
The Giants already lost lead back Saquon Barkley to a knee injury, and now the team's No. 1 wide receiver has a health concern. The potential exists for Shepard to return, but in the meantime position mates Darius Slayton, Golden Tate, Damion Ratley and C.J. Board will hold down the fort.