Shepard (hamstring) has been ruled out for Sunday's game against the Saints, Pat Leonard of the New York Daily News reports.
Shepard hasn't been able to practice all week after hurting his hamstring Week 3 against Atlanta. With fellow wide receiver Darius Slayton also sidelined by a hamstring injury, the Giants likely will lean on the likes of Kadarius Toney and Collin Johnson alongside Kenny Golladay against the unforgiving Saints secondary.