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Little (knee) has been ruled out ahead of Sunday's game against the Colts.
Little is expected to miss his first game this year after he suffered a knee injury during Jacksonville's Week 5 win over Buffalo. The third-year lineman didn't practice all week, and he's expected to undergo further testing on his knee in the near future. Tyler Shatley will likely be the next man up at left guard for the Jaguars.
