Hayne was promoted to the active roster from the 49ers practice squad Saturday.
The 49ers placed guard Alex Boone on injured reserve Saturday, which opened a spot on the active roster for the versatile Hayne. He has been on the 49ers practice squad since re-signing with the team in November, and now that Shaun Draughn has been ruled out for Sunday, Hayne could provide some depth in the run game behind Kendall Gaskins and DuJuan Harris in addition to potentially serving as a returner.