The Lions placed Jefferson on the practice squad injured list Wednesday due to an unspecified issue.
Jefferson will be ineligible to take part in practices with the Lions for the remainder of the postseason while he recovers from the injury. The 23-year-old running back logged 15 carries for 74 yards and two touchdowns over seven appearances as a rookie with the Lions in 2021 but hasn't seen any game action since while spending both of the past two seasons on Detroit's practice squad.