Parham (knee) has been ruled out for Sunday's game against the Browns, Brian Costello of the New York Post reports.
A knee injury prevented Parham from practicing all week. He'll miss a second game in a row as a result of his injury, and his next chance to play is Week 6 against the Patriots on Sunday, Oct. 18. Jordan Meredith figures to once again start at left guard in Parham's absence.