Melifonwu (ankle) has been ruled out for Sunday's game against Houston.
Melifonwu has been on injured reserve since late September due to an ankle injury he suffered in Week 1, but his 21-day practice window to return from IR opened Wednesday, per Tim Twentyman of the Lions' official site. He was a full practice participant all week, and while he won't suit up Sunday, he has good chance at playing in Week 11 against Jacksonville on Sunday, Nov. 17.