Moore (ankle) is listed as active Monday in New Orleans, Tim Twentyman of the Lions' official site reports.
After missing two games due to an ankle injury, Moore practiced in full all week, blazing a trail for his return to the lineup. He's only been targeted more than three times in four of 11 outings this season, but in his first game at the Superdome since leaving New Orleans after the 2013 season, he'll aim to join the many wideouts that have reached the end zone against the Saints this season (21 times in all).