Stafford is unlikely to play Thursday against the Bills, Dave Birkett of the Detroit Free Press reports.
Stafford figures to be held out by the Lions as they preserve his health heading into Week 1 of the regular season. Dan Orlovsky and Jake Rudock are expected to handle the duties at quarterback, but will be throwing to a below average receiving corps with the team expecting to have Golden Tate and Marvin Jones on the sideline.