Quarless (knee) was activated from the IR/designated-to-return list Monday, Rob Demovsky of ESPN.com reports.
Quarless is set to make his first appearance since suffering a sprained MCL in Week 3. During his absence, Richard Rodgers has taken control of the starting TE spot, but Quarless could make an immediate impact in the red zone, where he picked up 15 targets in 16 games last season.