Henderson suffered a concussion and won't return to Sunday's game against the Colts, Darin Gantt of the Panthers' official site reports.
Henderson's exit will be a blow to the team's secondary, which is already without Vonn Bell (quadriceps) and has also seen Xavier Woods exit early Sunday with a thigh injury. With Henderson sidelined, Troy Hill and D'Shawn Jamison will be the likeliest candidates to see extra snaps against Indianapolis.