Tuttle (foot) has been ruled out ahead of Sunday's game against the Raiders.
Tuttle was listed as doubtful Friday after logging as a DNP for all three practices, and he won't travel with the team to Las Vegas. The 28-year-old nose tackle's next chance at suiting up will be Week 4 against the Bengals on Sept. 29. Nick Thurman is the next man up at nose tackle for the Panthers, and he'll anchor the interior of the defensive line alongside Jayden Peevy and A'Shawn Robinson (knee).