Smith (knee) has been ruled out for Sunday's game in Detroit, Max Henson of the Panthers' official site reports.
Listed as a non-participant throughout the week, Smith will sit out for a fourth straight game. Smith was able to resume running a few days ago, perhaps giving him a chance for a return Week 12 against Seattle. With Smith sidelined for at least one more contest, D.J. Moore will likely earn another starting assignment, while Curtis Samuel and Jarius Wright may also benefit from a few extra snaps.