Brown, who was officially placed on injured reserve Saturday, is expected to miss about six weeks due to a right high-ankle sprain, Ian Rapoport of NFL Network reports.
The Patriots deactivated Brown just three days after he sustained the injury in the third quarter of Wednesday's 13-10 loss to the Seahawks. Though recovery timelines for high-ankle sprains often range from 4-to-6 weeks, the Patriots quickly determined that Brown's injury is "a little more serious," which likely takes a return from IR in Week 6 when first eligible off the table. While their No. 1 wideout is sidelined until early November, the Patriots will have to lean more heavily on Romeo Doubs, DeMario Douglas, Mack Hollins and Kyle Williams as their primary receivers.