Kupp suffered an ankle injury during Sunday's game at Arizona.
Kupp needed assistance to get to the locker room just before halftime while walking with a noticeable limp and didn't rejoin his teammates on the sideline after the intermission. The Rams deemed him doubtful to return, so he seems destined to end Week 2 with four catches (on six targets) for 37 yards. With Puka Nacua (knee) on injured reserve, the Rams' existing receiving corps is perilously thin, as Demarcus Robinson, Tyler Johnson, Tutu Atwell and Jordan Whittington are the remaining healthy options for Week 2.