Gwyn (ankle) is set to miss significant time, Clifton Brown of the Ravens' official site reports.
Gwyn suffered a serious ankle injury during the Ravens' Week 3 win over the Cowboys in Rio. The starting center will likely be transferred to injured reserve soon as he focuses on recovering from the injury for a potential late-season playoff push. Olaivavega Ioane is set to start at center for Sunday's game against the Titans.