Ruiz (ankle) has been ruled out for Sunday's contest against the Giants, Katherine Terrell of ESPN.com reports.
Ruiz suffered an ankle injury in the team's 31-19 loss to the Bills in Week 4, and he will now be forced to miss at least one contest as a result. In his place, Dillon Radunz (toe) and Torricelli Simpkins are the top candidates to draw the start at right guard versus New York.