Seahawks head coach Mike Macdonald said Monday that Nwosu (thigh) has been ruled out for Thursday's matchup against the 49ers, John Boyle of the Seahawks' official site reports.

After missing the Seahawks' first four games of the season while recovering from a preseason knee injury, Nwosu made his 2024 debut in Sunday's loss to the Giants. He tallied three tackles over 20 snaps before sustaining a new injury that will keep him sidelined for at least one game. Dre'Mont Jones, Derick Hall (foot) and Boye Mafe (knee) will be the primary candidates to pick up snaps on the edge while Nwosu is out.