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Frazier sustained an ankle injury during Sunday's game in Las Vegas, Burt Lauten of the Steelers' official site reports.
In the middle of the third quarter, a Raider defender fell into the back of Frazier's leg, causing him to remain on the turf for some time as Steelers trainers checked him out. He then went to the sideline tent, yielding center to backup Ryan McCollum.
