Smith (foot) was carted off the field during Wednesday's practice, Adam Schefter of ESPN reports.
Practice had to stop when the offensive tackle was carted off. Smith was set to be the starting right tackle for the Texans, meaning if the foot issue is severe, the offensive line will take a huge blow headed into the opening-day contest with the Bills. If Smith must miss time, Trent Brown or Blake Fisher will likely start the season at tackle or guard.